- MENU - BLOG → Gardening & Landscaping → Pollinators → Shrubs → Wildlife → Sedges & Grasses → Woodland & Shade → Site Conditions & Situations → Seed Mixes → No Mow Lawn PrairieNursery.com How to Make a Homemade Weed Killer Having invested in native plants for their ecological benefits, many of our customers seek alternatives to commercial herbicides that will let them maintain and nurture a healthy environment. We are often asked about the safest and surest way to get rid of weeds. Pulling weeds by hand is always safest, and for small scale problems it is the best option. But there are times when herbicides may be more practical. Fortunately there is an alternative, a homemade weed killer made up of natural ingredients from the pantry that can get the job done. The Recipe Pour 1 gallon of white vinegar into a bucket. 5-percent household white vinegar is fine. It may take two or three days longer to kill the weeds with the lower concentration, but it does wo...